ASADA Masahito Associate Professor

My DreamReveal the mechanism of parasitism

ThemeTo understand the mechanisms of protozoan parasitism and find a way to control the diseases, we are studying on functional genomics of protozoan parasites and performing field epidemiology of the diseases.

Field

Protozoan disease, Genetic engineering, Molecular epidemiology

Keyword

Parasite, Piroplasma, Babesia, Malaria

Instructable research topic for doctoral thesis

家畜のピロプラズマ病及びマラリアの研究を行います。

  • 原虫の赤血球寄生に関する細胞生物学
  • 原虫のゲノム改変など遺伝子工学手法の開発やゲノム解析
  • ピロプラズマ病や偶蹄類マラリアの国際フィールド疫学

Message

 寄生虫は巧みに哺乳類宿主やベクターの中で形を変えながら増殖し、その生活環を維持しています。寄生虫学は多くのステージ名、宿主やベクターの名前を覚えないといけないと敬遠される方も居るかもしれませんが、生きた寄生虫を見るといかに彼らが巧妙なメカニズムで寄生生活を営んでいるか分かると思います。
 地球規模感染症学分野ではバベシア原虫やマラリア原虫を対象に、最新の遺伝子工学技術を用いた細胞生物学研究を行っています。また、海外を中心に、原虫病の国際疫学調査も行っています。もし国際的な仕事、遺伝子工学、原虫病などに少しでも興味があれば、是非研究室を覗いてみてください。

Academic degree Ph.D
License D.V.M.
Room addressGeneral Research Building 4
Room number108
Mail address masada atmark obihiro.ac.jp

Belongs

National Research Center for Protozoan Diseases/Department of Global Cooperation/Research Unit for Global Infection ControlResearch Center for Global Agromedicine/Department of Veterinary Medicine

Introduction

  • Study on Babesia
    In recent years, advances of methods to genetically manipulating apicomplexan parasites have enabled the study of their behavior within their hosts. We have developed gene disruption method on Babesia bovis and recently we suceeded to develop genome editing technique on the parasite. Using these techniques, we revealed the biological features of Babesia such as, gliding motility of Babesia merozoites, and erythrocyte modification by the parasites.

 

  • Study on ungulate malaria parasites
    Malaria parasites of even-toed ungulates were first observed in 1913, however its epidemiology was not well known until recent years. We performed molecular epidemiological survey in Southeast Asian countries, and we found Plasmodium was readily detectable from water buffaloes and goats in these areas.
GFP and RFP expressing B. bovis. The parasite was produced by sequential transfection technique.
Epidemiological survey on ungulate malaria (in Thailand).

List of current research topics

  • Mechanisms of host erythrocyte modification by piroplasma parasites
  • Erythrocyte invasion mechanisms of piroplasma parasites
  • Epidemiology and pathology of ungulate malaria parasites
Related industries Animal hygiene, Medical, pharmaceutical
Affiliated academic society The Japanese Society of Veterinary Science, Japanese Society of Parasitology, Japanese Society of Tropical Medicine, The American Society for Microbiology