IWASAKI Ryota Associate Professor

ThemeChallenge to improve prognosis based on prevention and treatment of cancer metastasis in veterinary medicine

My DreamAchieving BNCT for veterinary medicine
  • Veterinary Medical Center


Veterinary Medical Center/Small Animal ClinicResearch Department/Department of Veterinary Medicine/Division of Clinical Veterinary Medicine/Section of Small Animal Clinical Sciences
Field Clinical Oncology, Radiation Oncology, Diagnostic Imaging, Boron Neutron Capture Therapy
Keyword Lymph node metastasis, CT, MRI, Ultrasonography, X-ray, Imagin diagnosis, Radiation therapy, Radiation induced side effects, BNCT, Boron Neutron Capture Therapy


I have been involved in two main areas of research: first, on cancer metastasis in companion animals, and second, on boron neutron capture therapy (BNCT).
1. Cancer in companion animals is highly malignant and often metastasizes to lymph nodes, liver, lungs, etc. at an early stage. Therefore, in order to predict and detect metastasis at an early stage, I have been studying highly accurate diagnostic methods using imaging tests. As one such method, we have established diagnostic criteria for sternal lymph node metastasis using CT. Currently, we are conducting clinical research on lymphography to identify the lymph node where cancer first reaches (sentinel lymph node).
2. BNCT is a revolutionary radiotherapy in which a boron drug, which is easily taken up by tumors, is administered followed by neutron irradiation, and the extremely short range particles produced by the nuclear reaction between the boron and neutrons attack tumor cells. I have been analyzing where and how much boron is incorporated into normal bone tissue and to what extent bone is damaged by BNCT. Currently, I am conducting basic experiments using cell lines to investigate the usefulness of BNCT for refractory cancer in dogs.

CT detection of metastases using the ratio of the height of the sternal lymph node to the sternal height.
Identification of sentinel lymph nodes using CT lymphography (yellow arrows)
Boron distribution imaging in murine tibia after administration of the boron drug BPA

List of current research topics

  • Basic Research on BNCT for Refractory Cancer in Dogs
  • Research on improving the accuracy of diagnostic imaging of lymph node metastases
  • Research on the effects of BNCT on normal tissues
  • Clinical research on therapeutic intervention for oligometastases
Related industries Veterinary Medicine, Radiology
Affiliated academic society Japan Veterinary Cancer Society, Veterinary Cancer Society, Japanese Society for Radiation Oncology, Japanese Society of Neutron Capture Therapy, Japan Cancer Association
Academic degree Ph.D.
License Veterinarian, Radiation protection supervisor
Room addressVeterinary Medical Center
Room number2F N204
Mail address ri5702 atmark obihiro.ac.jp