MIYAMOTO Akio Specially Appointed Professor

Theme"A reoadmap to the pregnancy in the first 7 days post-insemination in the cow: Immune cross-talk of sperm and early embryo in the oviduct and uterus"

My DreamDevelopment of new technology for frozen semen and producing embryos to improve fertility in cattle

Belongs

Research Department/Department of Life and Food Sciences/Division of Animal Production/Section of Life Science
Faculty (Unit)Animal Production Program
Grad school (Course)Doctoral and Master's Program of Animal Science and Agriculture/Animal Production Science
Field Animal Reproduction, Reproductive Immunology, Endocrinology, Reproductive Pathophysiology, Sperm/Embryo
Keyword cattle, immune system, uterus, oviduct, sperm, embryo, immune cell, maternal recognition of pregnancy, attack, tolerance
Fig. 1: Cryopreserved bull sperm are released in the cow uterus, but most of sperm receive attack of immune cells or are excluded to vigina by backflow (Mol Reprod Dev 85; 2018, Cover page).
Fig. 2: A schematic representation of impact of bovine oviduct epithelial cell (BOEC)-sperm-polymorphonuclear neutrophil (PMN) interaction for physiological changes in local immunity in the bovine oviduct during the period between estrus and ovulation. The LH-surge and sperm-BOEC binding stimulate epithelial cells to secrete high levels of PGE2 that strongly suppresses the PMN phagocytic behavior to sperm (Dom Anim Endocrinol 56, 2016).
Fig. 3: Our proposed model of the communication of the developing embryo with epithelium and immune cells in the cow oviduct. First, an immunological crosstalk exists between the embryo and oviduct epithelium; where the embryo generates an anti-inflammatory response in oviduct epithelium, and the oviduct epithelium helps the embryo to secrete IFNT by either physical contact and/or via releasing some factors. The embryoderived IFNT then regulates gene expression of immune cells towards an anti-inflammatory response (Scientific Reports 8: 7050, 2018).
Affiliated academic society Society for the Study of Reproduction (SSR), Society for Reproduction and Development (SRD), Japanese Society of Animal Science (JSAS)
Editor Domestic Animal Endocrinology
Editorial Board
  • Journal of Reproduction and Development (JRD)
Academic degree D.Agr.
Room addressGeneral Research Building 1
Room numberE2202-4
Mail address akiomiya atmark obihiro.ac.jp
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