Obihiro University of Agriculture and Veterinary Medicine

My lab focuses on the intracellular regulatory mechanism of ion transport protein function expressed in exocrine glands, such as salivary glands, and epithelial cells. I'd like to move my research forward by comprehensively using electrophysiological, molecular and cell biological methods and organ and tissue perfusion methods. For example, one theme is to identify membrane transport protein molecule groups that exist in the parotid gland of ruminants such as bovines. The groups enable amazing substance transport (particularly of bicarbonate ions and phosphate ions). Another theme is the identification of the function control molecule groups that control the membrane transport protein molecule groups. In addition to these studies, I hope to contribute to the understanding and treatment of human diseases caused by the structure and dysfunction of ion channels and transporters (i.e., channelopathies and diseases of transporters) through basic studies on cell physiology using porcine tracheal mucosa epithelium and ciliated epithelial cells.

• Intracellular regulation mechanism of electrogenic sodium bicarbonate ion cotransporter functionally expressed in bovine parotid acinar cells
• Electrophysiological properties and molecular basis of divalent cation-permeable ion channels functioally expressed in bovine parotid acinar cells
• Electrophysiological properties of epithelial sodium channel functionally expressed in porcum tracheal fibrous epithelial cells
• Calcium-activated potassium transport pathway functionally expressed in the basolateral membrane of the mandibular acinar cell of the rat