Toru ISHIKAWA Professor

My DreamIdentification of novel ion channels and transporters, and elucidation of their physiological functions

ThemeIntracellular regulation mechanisms and structure-function relations of epithelial ion channels and transporters.

Field

General physiology, Cell physiology, Epithelial membrane transport, Molecular physiology of ion channel and transporter

Keyword

Calcium-activated potassium channel, Epithelial sodium channel, Bicarbonate-permeable anion channel, Voltage-activated chloride channel, Divalent cation-permeable TRPM6/7 channel, Electrogenic sodium bicarbonate cotransporter, Electrogenic sodium phosphate cotransporter, Epithelial bicarbonate transport, Epithelial sodium transport, Epithelial tissue, Exocrine, Ruminant parotid gland acinar cells, Porcine tracheal ciliated epithelial cells

Instructable research topic for doctoral thesis

  • 上皮細胞に機能発現するイオンチャネルおよびトランスポーターの構造機能連関と細胞内調節機構に関する研究
  • ウシ耳下腺腺房細胞の重炭酸イオンやリン酸イオン分泌を支える分子基盤とその細胞内制御機構に関する研究
  • ブタ気管線毛上皮細胞に機能発現するイオンチャネルのナトリウム輸送における役割に関する研究

Message

一般生理学や細胞生理学、特に上皮膜輸送やイオン輸送蛋白機能に興味がある学生さんは是非気軽に研究室にお立ち寄りください。共同獣医学課程や大学院動物医科学コースにおける生理学関連の講義・実習、その他生理学に関する質問も大歓迎です。

Academic degree D.Vet.
License Veterinarian
Self introduction

I've been interested in general physiology and cell physiology since my school days, and I've studied the functions and intracellular regulatory mechanisms of ion channels and transporters, which are important for substance transport in epithelial tissues and epithelial cells.

Room addressGeneral Research Building 1
Room numberS1105-1
Mail address torui atmark obihiro.ac.jp

Belongs

Research Department/Department of Veterinary Medicine/Division of Veterinary Sciences/Section of Physiology and PharmacologyOffice for International Accreditation of Veterinary Education/Staff

Introduction

My lab focuses on the intracellular regulatory mechanism of ion transport proteins functionally expressed in exocrine glands, such as salivary glands, and epithelial cells. I'd like to move my research forward by comprehensively using electrophysiological, molecular and cell biological methods and organ and tissue perfusion methods. For example, one theme is to identify membrane transport proteins (i.e.,ion channels and transporters)  that exist in the parotid gland of ruminants such as bovines. The proteins enable amazing membrane transport (particularly of bicarbonate ions and phosphate ions). Another theme is the identification of intracellular regulatory proteins that control the membrane transport proteins. In addition to these studies, I hope to contribute to the understanding and treatment of human diseases caused by abnormalities of  structure and function of ion channels and transporters (i.e., channelopathies and transportopathy) through basic studies on cell physiology using porcine tracheal epithelium and ciliated epithelial cells.

List of current research topics

  • Molecular and cellular regulatory mechanisms of electrogenic sodium bicarbonate cotransporter functionally expressed in bovine parotid acinar cells
  • Electrophysiological properties and molecular basis of potassium channels and divalent cation-permeable ion channels functioally expressed in bovine parotid acinar cells
  • Electrophysiological properties and molecular basis of potassium channels and epithelial sodium channel involved in electrogenic sodium transport in ciliated epithelial cells of porcine trachea
  • Calcium-activated potassium transport pathway functionally expressed in the basolateral membrane of rat mandibular acinar cells
Related industries Medicine, Veterinary Medicine
Affiliated academic society Physiological Society of Japan, Japanese Society of Veterinary Science
Academic background 1984 Bachelor, School of Veterinary Medicine, Hokkaido University
1986 Master's Course, Graduate School of Veterinary Medicine, Hokkaido University
1989 Doctoral Course, Graduate School of Veterinary Medicine, Hokkaido University
1989-1992 Post Doctoral Researcher, Department of Physiology, The University of Sydney
1992-1998 Research Fellow, National Institute for Physiological Sciences
1995-1998 Ministry of Education Overseas Researcher and Visiting Researcher, SickKids, Toronto, Canada
1997-1998 Absense from Research Work, National Institute for Physiological Sciences
1998-2009 Associate Professor, Graduate School of Veterinary Medicine, Hokkaido University
2009-2017 Professor, Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
2017- Professor, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine