Salmonella are classified into as many as 2,700 serovars according to the combination their somatic and flagellar antigens. Many of the pathogenic serovars cause diarrhea and other gastrointestinal symptoms in a variety of animals (food poisoning in humans). On the other hand, only a few serotypes (less than 10) cause septicemia in specific animals, leading to death. However, the mechanism that causes this strong host-specific virulence has not yet been elucidated. We have identified 50 antigens that are expressed by serovar Gallinarum (fowl typhoid) in infected chickens. We have also used mutant strains lacking the genes encoding these antigens to elucidate how these genes are involved in the pathogenesis of fowl typhoid, and been attempting to identify the genes essential for host-specific virulence and lethality and the mechanisms involved, compared with those of serovar Typhimurium, which has been commonly used in studies of Salmonella. We are also currently working on serovars Dublin and Abortusequi, which infects cattle and horses, respectively, and hope to eventually update our overall understanding of the pathogenicity of Salmonella spp. Through this research, we hope to unravel the history of the co-evolution of pathogenic bacteria and their host animals, and furthermore, to elucidate how zoonotic pathogens have become able to infect various animal species, thereby contributing to the development of control measures for human and animal infectious diseases.
List of current research topics
Elucidation of pathogenic mechanisms of fowl typhoid/pullorum disease
Epidemiological investigation of bovine salmonellosis and establishment of control strategies
Elucidation of pathogenic mechanisms of equine paratyphoid
The Japanese Society of Veterinary Science, The Japanese Society on Poultry Diseases, Japanese Society for Bacteriology, Japan Society of Veterinary Epidemiology, Japanese Society of Zoo and Wildlife Medicine, Japanese Society of Food Microbiology
Journal of Veterinary Medical Science: 2024-
Ph.D.in Veterinary Sciences
I was born in Osaka , but have spent more than half of my life in Aomori and Hokkaido. I have mainly conducted research on salmonellosis in poultry. In Obihiro, I am continuing this and starting research on salmonellosis in cattle and horses. My hobbies are reading, traveling, and eating. Thanks to the delicious food in Obihiro, I have gained about 10 pounds in the three years since I was appointed here, and I need to resume some workout.