Naoto Hashimoto Associate Professor
ThemeInvestigation of physiological roles of food components in mammales and involvement of vagus nerve in the roles
BelongsResearch Department/Department of Life and Food Sciences/Division of Food Science/Section of Food Technology and Biotechnology
|Field||Food and nutrition, Nutritional biochemistry, Nutritional physiology|
|Keyword||flavonoids, non-alcoholic fatty liver disease (NAFLD), bile acids, vagus nerve, adipokines|
Flavonoids are water-soluble phytochenimals in foods and can be hardly found in our blood. Thus, physiological activities of flavonoids are often denied. However, we showed that flabonoids can stimulate hepatocytes. On the other hand,as HBVN was involved in the reduction of blood adipokine concentrations in rodents with non-alcoholic fatty liver disease, namely NAFLD, we focus hepatic branch of vagus nerve (HBVN) that links the liver to the central nerve system . Now, I hypothesize that HBVN can mediate stimulation to hepatocytes with flavonoid to other organ, and will try to proven the hypothesis in this university.
List of current research topics
To reveal expenditure mechanisms of fatty acids in feeding flavonoids.
To investigate mechanisms of reduction of blood adipokine concentrations in NAFLD rodents induced by bile acids and involvement of HBVN in the reduction.
To investigate mechanisms of expression of flavonoid-metabolizing enzymes regulated by bile acids.
|Affiliated academic society||The Japan Society of Nutrition and Food Science, The Japanese Biochemical Society, The Physiological Society of Japan|
As I had investigated physiological functions of crops and vegetabels in rats and mice in NARO for more than 15 years, I will investigate mechanisms of physiological functions of food components using rodents and involvement of nerve system in the mechanisms in this university. Additionally, I sometimes enjoy badminton and fishing. Let's enjoy the Tokachi life.
|Room address||General Research Building 3|
|Room number||Room 606|
|Mail address||hasshy obihiro.ac.jp|