Noboru Inoue Professor

ThemeDevelopment of diagnostic, therapeutic, and preventive methods for animal trypanosomoses (AT), and epidemiological studies for AT. Research on the mechanisms of cell differentiation in African trypanosome in progress of its life-cycle.

Belongs

National Research Center for Protozoan Diseases/Department of Global Cooperation/International Cooperation UnitResearch Center for Global Agromedicine/Department of Veterinary Medicine
Field Protozoology, Parasitology, Epidemiology
Keyword Trypanosome, Vector, Life cycle, Host-parasite interactions, Cell differentiation, Cell surface molecules, Epidemiological surveys, Diagnostics, Therapeutics, Prophylactic drugs and vaccine

Introduction

Variety of trypanosome species had been reported from human and animal hosts. Interestingly, their virulence to hosts is ranging from avirulent to high that cause fatal trypanosomosis. Each trypanosome species has various phenotypes in terms of host/vector-parasite relationships, such as trypanosome species with high or low host specificity, different mode of transmission namely biological transmission, mechanical transmission, and sexual transmission. In addition, some species are parasitized into host cell, while others are obligate extracellular parasite, making them formidable enemies that will use whatever means necessary to survive. Unfortunately, our current control measures to combat trypanosomoses are limited, i.e., early diagnosis followed by isolation of patients and affected animals, treatment with drugs which often cause severe adverse effects, and vector control. To improve the current situation, we are conducting development of simpler, affordable, and more accurate diagnostic methods, safe therapeutic agents, and vaccines, as well as to analyze the prevalence and risk factors of the disease.

Another research project focuses on the survival strategies of trypanosomes as parasitic organisms. Trypanosomes can survive within their mammalian hosts and vectors (often insects), which have completely different internal environments. However, mechanisms of their life-cycle development and environmental adaptation are largely unknown. Our research is particularly focused on the identification and functional analysis of developmental stage-specific surface molecules. This basic research is also being conducted in the hope that it will lead to the development of future transmission blocking vaccines and therapeutics that target the cell differentiation mechanisms of trypanosomes.

Field study in Mongolia
Diagnostic kit developed in collaboration with the Institute of Veterinary Medicine, Mongolia
Diagnostic kit developed in collaboration with the Institute of Veterinary Medicine, Mongolia

List of current research topics

The following topics related to eradication of animal trypanosomoses

  • 1. Development of diagnostic methods
  • 2. Development of therapeutic agents and elucidation of their modes of action
  • 3. Development of prophylactic methods (vaccines and prophylactic drugs) and elucidation of their modes of action
  • 4. Epidemiological studies and risk factor analyses

The following topics related to trypanosomes as parasitic organisms

  • 1. Interactions with hosts and vectors via cell surface molecules
  • 2. Elucidation of mechanisms of environmental adaptation such as cell differentiation during life cycle progression
Related industries Veterinary Science, Animal Science, Veterinary Pharmaceutical, Food Safety, Environmental Science, Wild Life
Project JICA/AMED SATREPS [Epidemiological Studies on Animal Protozoan Diseases in Mongolia and Development of Effective Diagnostics Measures]
OIE Non Tsetse Transmitted Animal Trypanosomoses Network
Affiliated academic society The Japanese Society of Veterinary Science, Japanese Society of Veterinary Parasitology, Japanese Society of Parasitology, Japanese Society of Tropical Medicine
Academic degree Ph.D.
License Veterinarian
Self introduction

I am from Tokushima Pref. My hobbies are reading and art appreciation. My specialty is parasitology and protozoology. I have been developing diagnostic methods for animal trypanosomoses, conducting epidemiological surveys, and studying the molecular mechanism of life cycle development of trypanosome. I have been an OIE Reference Laboratory Expert (Surra) since June 2007 to present.

Room addressNational Research Center for Protozoan Diseases
Room number102
Mail address ircpmi atmark obihiro.ac.jp