Uemura Akiko Associate Professor

My DreamControls on congenital heart disease and post-operative adhesions

ThemeDevelopment of minimally invasive surgery (interventional radiology) and treatment devices
Elucidation of the pathogenesis of congenital heart malformations and congenital vascular malformations
Development of a post-operative anti-adhesion agent using hyaluronic acid

Field

Small Animal Surgery, Cardiology, Operative Studies, Biomedical Materials

Keyword

Heart disease, Congenital heart defect, Congenital vascular malformation, Tracheal collapse, Interventional radiology, Minimally invasive surgery, Post-operative adhesion, Biomaterials, Hyaluronic acid, Regenerative medicine

Instructable research topic for doctoral thesis

軟部外科(外科学、手術学)に関連したテーマ
犬猫の循環器に関連したテーマ
インターベンション治療に関連したテーマ
ヒアルロン酸や人工臓器等の生体材料に関連したテーマ

Message

東京農工大学小動物外科専門医レジデント時代は叩き上げの外科医として徹底的に鍛えられました。先天性心疾患を主体とする多様な循環器症例の内科的・外科的治療も行っており、特に犬の先天性心奇形として好発する動脈管開存症(PDA)は年間30例程度執刀しています。
一方で獣医師として大学に勤めながら筑波大学で生体材料高分子ポリマーの分解をテーマにPhDを取得しており、獣医学という領域に囚われることなく、医学・農学・薬学・工学等の多様な分野との連携が素晴らしい成果を生み出すことを目の当たりにしてきました。
先達の教えと学生の皆さんが持つ「なぜ?」が融合して初めて新たな領域が切り開けるのだと思っています。犬猫の外科疾患や循環器疾患に興味があり、やる気にあふれる方々の来訪を楽しみにしています。

Academic degree Doctor of Philosophy in Agricultural Science
License Veterinarian, Diplomate JCVS (Japanese college of veterinary surgeons)
Self introduction

I was born in Taito-ku, Tokyo and raised in Adachi-ku, Tokyo. I love sweets and fruits, both Japanese and Western. My one weakness is the cold, so I am anxiously awaiting winter in Tokachi.
Seeing dogs and cats leave the hospital with their owners after surgery, looking so happy is a very meaningful moment for me.

Room addressCompanion Animal Research Building
Mail address auemura atmark obihiro.ac.jp

Belongs

Research Department/Department of Veterinary Medicine/Division of Clinical Veterinary Medicine/Section of Small Animal Clinical SciencesVeterinary Medical Center/Small Animal Clinic

Introduction

My main areas of research are soft tissue surgery and cardiology in dogs and cats.
The first one is the development of minimally invasive surgery and devices in small cases, such as small dogs and cats. Interventional treatment in cases of light weight and low circulating blood volume is performed under open chest without open heart. I've been exploring the adaptation of the novel device to a hybrid technique where the device is inserted directly into the heart. This method is not affected by vessel diameter. This method does not depend on the diameter of the blood vessels, making it possible for small dogs and cats to use the large device and to use a heart-lung machine. It is not as invasive as the open heart surgery used, which can also reduce the surgical risk.
As one of the minimally invasive treatment options, a new tracheal stent for tracheal collapse in dogs has also been indicated in 2017. I'm working on it. A new stent with a different knitting method for Nitinol is already being extended to various diseases in human medicine device with superior tissue-following capability compared to conventional tracheal stents, which is expected to reduce post-operative complications. I am the second person in Japan to earn a new stent trainer certificate. I also provide hands-on guidance for the implantation of new tracheal stents for tracheal collapse in veterinary hospitals across the country.
I also found dogs and cats that were deemed unsuitable for sale and out of the general sales routes, especially in cases with congenital malformations. We are also involved in many treatments. In recent years, we have been investigating the pathogenesis of congenital heart malformations and vascular malformations in collaboration with several universities.
In addition, the development of post-operative adhesive-prevention agents using hyaluronic acid is another major focus of my research.Post-operative adhesions are a major problem, especially in human medicine, because of the high rate of post-operative adhesions. In order to address this problem, we have been working together with other universities and companies to develop anti-adhesion agents for post-operative period. We have reported on the effectiveness of insolubilized hyaluronic acid as an anti-adhesion agent to prevent postoperative adhesion in an open-chest model. Since we were able to clarify the effect of the degradation process of insoluble hyaluronic acid over time and the effect of swelling rate on the degradation rate, we are conducting research with a view to developing new applications for hyaluronic acid preparations.

Intraoperative transesophageal echocardiography in the canine Cor Triatriatum Dexter
Implantation of a new tracheal stent in dogs with a tracheal collapse (Pre-operative CT)
Implantation of a new tracheal stent in dogs with a tracheal collapse (Post-operative chest radiographs)
Insertion of postoperative anti-adhesion agent with insoluble hyaluronic acid in thoracoscopic surgery (VATS)(Insert A to D in that order)

List of current research topics

Modifications in the pathogenesis and treatment of patent ductus arteriosus (PDA) in very low weight patients
Development of minimally invasive surgery (interventional treatment) and treatment devices
Elucidation of the pathogenesis of congenital heart malformations and congenital vascular malformations in dogs and cats
New tracheal stent therapy for tracheal collapse
Hyaluronic acid drugs are indicated for the treatment of post-surgical adhesions and contractures
Development of novel surgical drapes
Electrocardiogram and heart rate variability analysis in cats and dogs

Related industries Medicine, Veterinary medicine, Pharmaceutics, Agricultural science, Biomaterials
Affiliated academic society Japanese Society of Veterinary Anesthesia and Surgery, Animal Clinical Research Foundation, Japan Endovascular Treatment Conference (JET), Asian Society of Veterinary Internal Medicine (AiSVIM), Japan Society for Veterinary Endoscopic Surgery, Japanese Society of Veterinary Imagings