Obihiro University of Agriculture and Veterinary Medicine

I have been involved in two main areas of research: first, on cancer metastasis in companion animals, and second, on boron neutron capture therapy (BNCT).
1. Cancer in companion animals is highly malignant and often metastasizes to lymph nodes, liver, lungs, etc. at an early stage. Therefore, in order to predict and detect metastasis at an early stage, I have been studying highly accurate diagnostic methods using imaging tests. As one such method, we have established diagnostic criteria for sternal lymph node metastasis using CT. Currently, we are conducting clinical research on lymphography to identify the lymph node where cancer first reaches (sentinel lymph node).
2. BNCT is a revolutionary radiotherapy in which a boron drug, which is easily taken up by tumors, is administered followed by neutron irradiation, and the extremely short range particles produced by the nuclear reaction between the boron and neutrons attack tumor cells. I have been analyzing where and how much boron is incorporated into normal bone tissue and to what extent bone is damaged by BNCT. Currently, I am conducting basic experiments using cell lines to investigate the usefulness of BNCT for refractory cancer in dogs.

• Basic Research on BNCT for Refractory Cancer in Dogs
• Research on improving the accuracy of diagnostic imaging of lymph node metastases
• Research on the effects of BNCT on normal tissues
• Clinical research on therapeutic intervention for oligometastases