概要
名称
生命平衡科学講座(白寿)第3期
設置期間
2020年11月1日~2025年3月31日(4年5か月間)
寄附者
株式会社白寿生科学研究所
代表取締役社長 原 浩之(はら ひろゆき)
講座趣意
我が国では超高齢化社会に突入以降、医療費の増大とその原資不足への懸念から予防医学の発展への期待が大きく、生命がその誕生から終末まで本来持つ生体機能を平衡に保つ働きについての総合的研究の拡充が望まれます。生命平衡科学講座(白寿)においては、超低周波(ELF)電界の生体への影響・効果に着目し、生殖系・免疫系・内分泌系・神経系における電界の作用点の探索と機能解析を行い、その結果、ELF電界が多くの疾患の原因となるストレスおよび炎症に対し有効性を示すことを突き止め、その効果の最適化のための電界デザイン(仕様)の整理を展開しています。電界によるストレス応答への抑制的効果は、身体的フレイルだけでなく社会的フレイル対策を含む予防医学への応用可能性を有すと考えられ、当講座では今後も国民の健康寿命の延伸に資する、さらなる研究と実用的技術の開発を進めます。
寄附予定総額
2千5百万円
スタッフ
職名 | 氏名 | 連絡先 |
---|---|---|
教授(併任) | 井上 昇 | ircpmi |
客員教授 | 原川 信二 | sharakawa_hakuju |
※メールアドレスは,@obihiro.ac.jpを省略してあります
研究成果
1 論文
Shinba, T., Nedachi, T., and Harakawa, S. 2024. Acute Treatment of 60-Hz Electric Field Increases Parasympathetic Activity in Depressed Subjects: A Pilot Study Using Heart Rate Variability Analysis. IEEJ Trans. Electr. Electron. Eng. in press (2024 Nov.)
https://doi.org/10.1002/tee.24240
Shinba, T., Nedachi, T., and Harakawa, S. 2024. Decreases in Sympathetic Activity Due to Low-Intensity Extremely Low-Frequency Electric Field Treatment Revealed by Measurement of Spontaneous Fluctuations in Skin Conductance in Healthy Subjects. Applied Sciences. 14: 9336.
https://doi.org/10.3390/app14209336
Suzuki, D., Kayama, Y., Suzuki, M., Toriumi, H., Fukushima, T., and Harakawa, S. 2024. Respiratory Gas Analysis in the Evaluation of Biological Effects of Electric Field Exposure in Mice. IEEJ Transactions on Electronics, Information and Systems. 144: 526–527, .
https://doi.org/10.1541/ieejeiss.144.526
Harakawa, S., Yoshioka, S., Nishimura, N., Nedachi, T., and Shinba, T. 2023. Heart Rate Variability Analysis for Evaluating Biological Effects of Electric Field Treatment. IEEJ Trans. Electron. Inf. Syst. 143:608-609.
http://dx.doi.org/10.1541/ieejeiss.143.608
Shinba, T., Nedachi, T., and Harakawa, S. 2023. Alterations in Heart Rate Variability and Electroencephalogram during 20‐Minute Extremely Low Frequency Electric Field Treatment in Healthy Men during the Eyes‐Open Condition. IEEJ Trans. Electr. Electron. Eng. 18:38-44.
http://dx.doi.org/10.1002/tee.23695
Harakawa, S., Hori, T., Hiramoto, T., Nedachi, T., Shinba, T., and Suzuki, H. 2022. Suppression of Glucocorticoid Response in Stressed Mice Using 50 Hz Electric Field According to Immobilization Degree and Posture. Biology (Basel). 11:1336.
https://pubmed.ncbi.nlm.nih.gov/36138815/
Harakawa, S., Nedachi, T., Shinba, T., and Suzuki, H. 2022. Stress-Reducing Effect of a 50 Hz Electric Field in Mice after Repeated Immobilizations, Electric Field Shields, and Polarization of the Electrodes. Biology (Basel). 11:323.
https://pubmed.ncbi.nlm.nih.gov/35205189/
Harakawa, S., Hori, T., and Suzuki, H. 2022. Effects of 50Hz Electric Field on a Mouse Model of a Decubitus Ulcer Produced by Skin Compression. IEEJ Trans. Electron. Inf. Syst. 142:1172-1173.
http://dx.doi.org/10.1541/ieejeiss.142.1172
Sato, K., Tatsunami, R., Nakata, A., Komatsu, K. I., Harakawa, S., Nedachi, T., Haketa, K., Inagawa, H., and Wakame, K. 2021. Effects of Kumaizasa (Sasa senanensis) Leaf Extract on Innate Immune Regulation in HEK293 Cells and Macrophages. Anticancer Res. 41:4093-4100.
https://pubmed.ncbi.nlm.nih.gov/34281880/
Shinba, T., Nedachi, T., and Harakawa, S. 2021. Extremely Low‐Frequency Electric Field Exposure Increases Theta Power of EEG in both Eyes‐Open and Eyes‐Closed Resting Conditions in Healthy Male Subjects. IEEJ Trans. Electr. Electron. Eng. 16:592-599.
http://dx.doi.org/10.1002/tee.23334
Nedachi, T., Shimizu, K., Suzuki, H., and Harakawa, S. 2021. Theoretical Increase in the Electric Force Exerted on Body Hair Owing to Superimposed Electric Fields with Optimized AC / DC Ratios. IEEJ Trans. Electr. Electron. Eng. 16:1159-1164.
http://dx.doi.org/10.1002/tee.23413
Nedachi, T., Haketa, K., Harakawa, S., Miura, N., and Wakame, K. 2021. Effect of combining sleep-promoting food intake and electric field application on sleep in healthy participants: A pilot study. Functional Foods in Health and Disease. 11:659.
http://dx.doi.org/10.31989/ffhd.v11i12.861
Harakawa, S., Hori, T., Nedachi, T., and Suzuki, H. 2020. Gender and Age Differences in the Suppressive Effect of a 50 Hz Electric Field on the Immobilization-Induced Increase of Plasma Glucocorticoid in Mice. Bioelectromagnetics. 41:156-163.
https://pubmed.ncbi.nlm.nih.gov/31833072/
Harakawa, S., Nedachi, T., and Suzuki, H. 2020. Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice. Sci. Rep. 10:20930.
https://pubmed.ncbi.nlm.nih.gov/33288776/
Hori, T., Nedachi, T., Suzuki, H., and Harakawa, S. 2018. Characterization of the suppressive effects of extremely-low-frequency electric fields on an stress-induced increase in the plasma glucocorticoid level in mice. Bioelectromagnetics. 39:516-528.
https://pubmed.ncbi.nlm.nih.gov/30091796/
Harakawa, S., Hori, T., Inoue, N., and Suzuki, H. 2017. Time-dependent changes in the suppressive effect of electric field exposure on immobilization-induced plasma glucocorticoid increase in mice. Bioelectromagnetics. 38:272-279.
https://pubmed.ncbi.nlm.nih.gov/28130781/
Hori, T., Inoue, N., Suzuki, H., and Harakawa, S. 2017. Configuration-dependent variability of the effect of an electric field on the plasma glucocorticoid level in immobilized mice. Bioelectromagnetics. 38:265-271.
https://pubmed.ncbi.nlm.nih.gov/28236325/
Hori, T., Inoue, N., Suzuki, H., and Harakawa, S. 2015. Exposure to 50 Hz electric fields reduces stress-induced glucocorticoid levels in BALB/c mice in a kV/m- and duration-dependent manner. Bioelectromagnetics. 36:302-308.
https://pubmed.ncbi.nlm.nih.gov/25821169/
Harakawa S, Hori T, and Tsuchiya, M. 2014. Environmental Assessment by Electric Field Imager. IEIEJ. 32:F21.
Tsuchiya, M., Shiozawa, T., and Harakawa, S. 2014. Electric field sensing and imaging by noninvasive parallel-plate sensor. IEICE Electronics Express. 11:20140745.
https://www.jstage.jst.go.jp/article/elex/11/18/11_11.20140745/_article
Harakawa, S., Hori, T., Inoue, N., Okano, H., Nedachi, T., and Suzuki, H. 2014. Effect of extensive electric field therapy in bone density. Japanese Society for Integrative Medicine. 7:60-66.
Hori, T., Harakawa, S., Herbas, S. M., Ueta, Y. Y., Inoue, N., and Suzuki, H. 2012. Effect of 50 Hz electric field in diacylglycerol acyltransferase mRNA expression level and plasma concentration of triacylglycerol, free fatty acid, phospholipid and total cholesterol. Lipids Health Dis. 11:68.
https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-11-68
Shinba, T., Takahashi, K., Kanetake, S., Nedachi, T., Yamaneki, M., Doge, F., Hori, T., Harakawa, S., Miki, M., Hara, H., Suzuki, H., and Hara, A. 2012. A pilot study on electric field therapy for chronic pain with no obvious underlying diseases. Japanese Society for Integrative Medicine. 5:68-72.
2 学会発表
Hori T, Nedachi T, Suzuki H, Harakawa S. 2018. Characterization of the suppressive effects of extremely-low-frequency electric fields on a stress-induced increase in the plasma glucocorticoid level in mice. The Joint Annual Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association PA-107.
Hori T, Suzuki H, Harakawa S. 2017. Anti-stress effects of exposure to a 50-Hz electric field in immobilized mice. The Joint Annual Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association PA-93.
甲田道明,下原光幸,貴志俊英,原川信二,(2016)高圧ケーブル端末部の電界イメージング. 電気学会全国大会講演論文集ROMBUNNO.1‐026
Harakawa S, Hori T, Tsuchiya, M. 2014. Environmental Assessment by Electric Field Imager. IEIEJ 32: F21.
Hori T, Inoue N, Suzuki H, Harakawa S. 2014. Effect of electric field that depresses an increase of plasma glucocorticoid induced by restriction, in general blood property, biochemistry and body weight. J Jpn Biomag Bioelectromag Soc 27: 74-75.
Hori T, Inoue I, Suzuki H, Harakawa S. 2013. Dose-dependent effects of exposure to electric field on plasma corticosterone level in restricted mice. J Jpn Biomag Bioelectromag Soc 26: 259-260.
Hori T, Harakawa S, Inoue I, H S. 2012. Dose dependent effect of electric field in plasma corticosterone level on restricted mice. J Jpn Biomag Bioelectromag Soc 25(1): 222-223.
3 特許
特許 2017-005390 検知出力装置 特許査定 登録 (日本)
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201803007271553609
特許 2015-559102 電界検知出力装置 特許査定 登録 (日本、中国、台湾)
特許 2014-145446 可視化装置および可視化方法 特許査定 登録 (日本、中国、台湾)
特許 2015-231165 電界調整システム 特許査定 登録