ThemeStudy on species difference and molecular evolution of enzyme related to drug metabolism
My DreamDiscover the evolution of detoxication system
Research Department, Department of Veterinary Medicine, Division of Veterinary Sciences, Section of Physiology and Pharmacology
Diagnostic Center for Animal Health and Food Safety, Toxicology Laboratory
Research Center for Global Agromedicine, Department of Veterinary Medicine
|Field of research||Molecular evolution, Environmental toxicology|
|Keyword||Cytochrome P-450, Glucuronic acid conjugation enzyme, Evolution, Species difference|
In the environment, there are large numbers of artificially synthesized chemical substances, such as plant poisons and naturally derived dioxins, as well as environmental pollutants and medicines. Sensitivity towards these chemicals varies from one animal species to another. For example, cats have partially lost xenobiotic-metabolizing enzymes called glucuronidation enzymes, so they're more prone than other animals to the side effects of medicines. It's important to clarify such differences among animal species and the backgrounds under which such differences emerge, in order to understand how medications and environmental pollutants affect animals.
Analysis of the genome database has clarified that glucuronidation enzymes are scant in carnivorous birds but abundant in herbivorous birds, and carnivorous birds are highly susceptible to chemical substances. (Refer to the figure “Phylogenetic and species differences in amounts of glucuronidation enzymes in birds.”) We provide basic information to contribute to medication treatment by investigating genes related to the metabolism of foreign agents in endangered species, such as Japanese cranes.
We aim to contribute to animal medication treatment and wildlife conservation by clarifying differences in chemical susceptibility among animal species and examining the evolutionary and genetic backgrounds of such species.
List of current research topics
- Study on molecular evolution of birds' gene related to drug metaborism
- Estimation of drug metaboric capacity in Japanese crane
- Study on species difference in drug metaboric gene between Polypteridae spp. and others
- Estimation of sensibility for ratiside in Ogasawara Islands endemic species
|Affiliated academic society||Japanese Society of Veterinary Science|
|Room address||General Research Building 4|
|Mail address||ykawai obihiro.ac.jp|