Staff

Adachi Mami

Assistant Professor

Theme

Development of diagnosis and treatment methods for malignant tumor (hemangiosarcoma) in dogs and cats

My Dream

Coexist with tumor

Belongs

Veterinary Medical Center, Small Animal Clinic

Research Department, Department of Veterinary Medicine, Division of Clinical Veterinary Medicine, Section of Small Animal Clinical Sciences

Field of research Clinical oncology, Tumor diagnostics, Tumor therapeutics
Keyword Endothelial progenitor cells, Hemangiosarcoma, Spleen, Dog

Introduction

Dogs and cats are longevity by medical progress, and old dogs and cats infected with tumor are visiting veterinarians. Malignant tumors are considered to be incurable diseases, and researchers are working hard every day to develop early diagnosis methods and new treatment methods for dogs and cats as well as humans. Among malignant tumors, I am studying canine hemangiosarcoma. Canine hemangiosarcoma is a malignant tumor derived from vascular endothelial cells and often occurs in the spleen. Metastasis rate is high, and present study has reported that survival time is about half a year by combination of surgery and chemotherapy, however, there is no more effective standard treatment. While investigating effective treatments for hemangiosarcoma, strong expression of surface antigens on endothelial progenitor cells (EPCs) and efficacy of molecular targeted drugs against them were found in canine hemangiosarcoma. See photos "Differentiation of EPC", "Strong expression of EPC surface antigen", and "Efficacy of molecular targeted drugs against EPC surface antigens". Because hemangiosarcoma is derived from vascular endothelium, it is hypothesized that these EPCs will become hemangiosarcoma. I am studying whether detecting and treating against these EPCs will enable establishment of early diagnosis and new treatment method in canine hemangiosarcoma. I have confirmed that EPC numbers has decreased before and after tumor removal, however, number of cases is still small. See photo "Change of EPC numbers before and after tumor removal". In the future, I will continue to detect these EPCs and research that may be useful for tumor diagnosis and treatment. "Cure tumor" is my final goal, however, I would like to always think about ways to "coexist with tumor" with dogs and cats suffering from tumors and their owners, and do medical treatment and research, I made it My Dream.

Differentiation of EPC
Strong expression of EPC surface antigen
Efficacy of molecular targeted drugs against EPC surface antigens
Change of EPC numbers before and after tumor removal

List of current research topics

Measurement of endothelial progenitor cell (EPC) numbers in canine hemangiosarcoma

Affiliated academic society The Japanese Society of Veterinary Science, Japan Veterinary Cancer Society, Hokkaido Veterinary Association
Academic degree PhD
License Veterinarian
Mail address adachim atmark obihiro.ac.jp