TAGAWA Michihito Assistant Professor

My DreamElucidate why dogs and cats develop tumors

ThemeEstablishment of tumor markers and development of new treatments in dogs and cats

Field

Clinical oncology, Medical oncology, Internal medicine, Tumor immunology

Keyword

Diagnostic marker, Immune checkpoint, Lymphoma, Gene, Dog, Cat
  • Veterinary Medical Center

Instructable research topic for doctoral thesis

  • 犬と猫の腫瘍マーカーの検索
  • 犬と猫の免疫チェックポイント発現解析
  • 犬と猫の免疫チェックポイント阻害療法に関する研究

Message

動物医療センターで内科系診療を担当しています。また専門は腫瘍内科、血液内科であり、症例の主訴、血液検査や画像診断から得られた異常所見をもとに病態を把握し、疾病の診断、治療を行う醍醐味を一緒に味わうことができればと思っています。所属学生は日常的に診療に参加して頂くため拘束時間も長くなりますが、症例を通じた貴重な経験を得ることが可能です。

研究に関しては、これまで牛ヘモプラズマ感染症の疫学調査や、犬乳腺腫瘍の超音波検査、腫瘍と免疫に関する研究など幅広く行ってきました。ですので学生の希望にあわせ、可能な範囲でやりたいことを指導していきたいと思っています。現在は腫瘍マーカーと免疫チェックポイントに関する研究を中心に行っています。

Academic degree D.V.M Ph.D
License Veterinarian
Self introduction

I'm from Sapporo, Hokkaido, and I love the Fighters and Consadole. I conduct medical examinations and research to resolve as many issues as possible regarding animal tumors.

Mail address mtagawa atmark obihiro.ac.jp

Belongs

Veterinary Medical Center/Small Animal ClinicResearch Department/Department of Veterinary Medicine/Division of Clinical Veterinary Medicine/Section of Small Animal Clinical Sciences

Introduction

Dogs and cats develop various tumors. However, there are few cases in which tumors are completely cured only with surgery, radiation and anticancer drugs, which are the three major treatments for tumors. New treatment strategies are needed. Fewer tumor markers have been identified in dogs and cats than in humans. Easy-to-use markers for diagnosis, prognosis and recurrence are desired.
A lymphoma is a hematopoietic tumor whose incidence is higher in dogs than in any other animal. It is a malignant tumor that is hard to completely cure with current standard treatments alone. Immune checkpoint blockade therapies have the potential to improve lymphoma treatment outcomes. I've evaluated immune checkpoint expression kinetics in lymphoma cases. Refer to the photos “lymphoma cytodiagnosis (upper left), flow cytometric analysis (upper right), immune checkpoint expression (lower left), relations to prognosis (lower right).”
There are fewer markers for the various tumors that occur in dogs and cats, so it's not easy to diagnose tumors or to monitor recurrence. I've focused on cell-free tumor DNA as a marker for various tumors by evaluating its expression in neoplastic diseases and its effectiveness as a marker.
Under the themes of “curing tumors that can't be cured” and “developing easy and effective tumor markers,” I'd like to contribute to animal health and society.

List of current research topics

  • Basic studies of immune checkpoint expression and establishment of new therapies in lymphoma affected dogs
  • Studies of analysis cell free DNA and application for tumor marker in canine lymphoma
Related industries Medicine, Veterinary medicine, Immunology
Affiliated academic society The Japanese Society of Veterinary Science, Japan Veterinary Cancer Society, Hokkaido Veterinary Medical Association
Academic background 2009 Bachelor, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
2009-2011 Private veterinary clinic
2014 Ph.D, the United Graduate School of Veterinary Sciences, Gifu University
2014-2015 Post Doctoral Researcher, School of Veterinary Medicine, Hokkaido University
2015-2017 Specially Appointed Assistant Professor, Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine
2017- Assistant Professor, Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine