TOMIHARI Mizuki Associate Professor

ThemeThe research for new vaccination therapy and diagnosis marker for melanoma in dogs
The research for new genetic causes for mast cell tumor in french-bull dog family

My DreamTo develop a new treatment method for mast cell tumor and melanoma in dogs and cats

Belongs

Research Center for Global Agromedicine/Department of Veterinary MedicineResearch Department/Department of Veterinary Medicine/Division of Clinical Veterinary Medicine/Section of Small Animal Clinical SciencesVeterinary Medical Center/Small Animal ClinicOffice for International Accreditation of Veterinary Education/Staff
Field Small animal surgery, Clinical oncology, Molecular biology, Genetics
Keyword melanoma, mast cell tumor, swimming puppy syndrome, regulatory T lymphocyte, hereditary disorders, immune tolerance, laparoscopy

Introduction

  1. Developing a new biomarker and vaccine treatment for malignant melanoma in dogs
    I've focused my attention on DC-HIL (a membrane protein that's involved in immune tolerance) and confirmed that it's expressed in canine malignant melanomas. I've also confirmed that certain anti-cancer effects can be achieved by combining a tumor-associated peptide vaccine for malignant melanoma and an anti-DC-HIL antibody. Further research is under way for the development of a new treatment and biomarker.
  2. Genetically examining a family of French bulldogs that were suspected of having familial mast cell tumors
    Mast cell tumors were found in a family of French bulldogs that was brought to the hospital. By conducting DNA microarray analysis for dogs with mast cell tumor (control group) that are genetically totally different from the family, I found 13 candidate genes that characterize the case group. Further examinations are under way to identify causative genes.
  3. Examining Labrador retrievers that presented the “swimmer puppy” syndrome
    A disease has been reported in which puppies have difficulty standing up and instead paddle their limbs as if swimming. I've conducted genetic, nutritional, and clinical examinations based on data of Labrador retrievers owned by Obihiro University of Agriculture and Veterinary Medicine and on data provided by the Hokkaido Association of Guide Dogs for the Blind to find causes and analyze pathological conditions.
melanoma cells
mast cell tumor cells
laparoscopic surgery
surgery

List of current research topics

  • The research for new vaccination therapy and diagnosis marker for melanoma in dogs
  • The research for new genetic causes for mast cell tumor in french-bull dog family
Affiliated academic society The Japanese Society of Veterinary Science, Japanese Society of Veterinary Anesthesia and Surgery, Japanese Society of Veterinary Clinical Pathology
Self introduction

I was born in Nakano City, Tokyo. I started working for Obihiro University of Agriculture and Veterinary Medicine in 2009. I make constant efforts while asking myself how I can bring students to enjoy learning the practical science of veterinary medicine, how I can provide the best treatment for patients and animal owners, and what I can do to achieve it.

Room addressVeterinary Medical Center 2F
Room numberN203
Mail address tomihari atmark obihiro.ac.jp