MINESHIGE Takayuki Assistant Professor

ThemePathogenesis studies of spontaneous animal diseases

My DreamTo contribute to connecting pathology with sick animals


Research Center for Global Agromedicine/Department of Veterinary MedicineResearch Department/Department of Veterinary Medicine/Division of Veterinary Sciences/Section of Anatomy and Pathology
Field Vererinary pathology, Laboratory animal science
Keyword Spontaneous disease, Dog, Cat, Common marmoset, Nonhuman primate, Atopic dermatitis, Skin disease


Atopic dermatitis (AD) is a chronic, pruritic, and allergic skin disease in humans and animals, particularly dogs. Canine AD (cAD) has received attention as a spontaneous atopic animal model because domesticated dogs inhabit a human environment, and cAD shares several clinicopathological features with human AD (hAD). I reported that IL-13 possibly derived from T helper 2 (Th2) cells stimulates periostin production in both keratinocytes and fibroblasts, and then periostin may play a critical role in the pathophysiology of cAD, particularly in the enhancement and chronicity of skin lesions via IL-25.
The common marmoset (marmoset) (Callithrix jacchus), is a New World primate that has been increasing number of used in biomedical and preclinical research in recent years. I proposed a novel chronic gastrointestinal disease ‘marmoset duodenal dilation syndrome’ characterised by an unexplained obstruction at the inferior flexure of the duodenum, ultimately resulting in duodenal dilation. Moreover, I established that imaging techniques such as contrast gastrointestinal radiography, plain radiography, and ultrasonography without anesthesia can be used to diagnose duodenal dilation.

Atopic dermatitis, skin, Shiba inu. The IL-13 mRNA-positive cells (arrows) are detected near the periostin mRNA-positive cells in the atopic skin. Double-In situ hybridization for PO (red) and IL-13 (blue). Bar = 50 μm T. Mineshige et al., J. Vet. Med. Sci. 80(1): 103–111, 2018
common marmoset ©︎ Copyright2021Central Institute for Experimental Animals https://www.ciea.or.jp/laboratory_animal/marmoset.html

List of current research topics

The study on the involvement of periostin in the pathophysiology of atopic canine skin
The pathological study on the spontaneous diseases observed in captive common marmosets

Related industries Veterinary science, Laboratory animal science, Veterinary dermatology
Affiliated academic society The Japanese Society of Veterinary Science, Japanese College of Veterinary Pathologists (JCVP), Japanese Association for Laboratory Animal Medicine (JALAM), Japan Society for Marmoset Research (JSMR)
Academic degree Ph.D.
License Veterinarian, Diplomate JCVP (Japanese College of Veterinary Pathologists)
Self introduction

I am a pathologist with experience as a clinical veterinarian. I would like to contribute connecting pathology with sick animals.

Room addressGeneral Research Building 1
Room numberS1103-1
Mail address mineshige atmark obihiro.ac.jp