■研究業績

○ Inaba, A., Komori, Y., Muroi, Y., Kinoshita, K., & Ishii, T.
Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice.
Neuroscience 320: 140-148, 2016

○ Iwai, M., Muroi, Y., Kinoshita, K., & Ishii, T.
Serotonin modulates the dehydration-induced changes in tolerance for bitter water.
Physiol. Behav. 151: 545-550, 2015

○ Nishikawa, Y., Furukawa, A., Shiga, I., Muroi, Y., Ishii, T., Hongo, Y., Takahashi, S., Sugawara, T., Koshino, H., & Ohnishi, M.
Cytoprotective effects of lysophospholipids from sea cucumber Holothuria atra.
PLoS ONE. 10(8): e0135701, 2015

○ Kinoshita, K., Tada, Y., Muroi, Y., Unno, T., & Ishii, T.
Selective loss of dopaminergic neurons in the substantia nigra pars compacta after systemic administration of MPTP facilitates extinction learning.
Life Sci. 137: 28-36, 2015

○ Matsushita, N., Muroi, Y., Kinoshita, K., & Ishii, T.
Comparison of c-Fos expression in brain regions involved in maternal behavior of virgin and lactating female mice.
Neurosci. Lett. 590: 166-171, 2015

○ Muroi, Y. & Ishii, T.
Neuropeptide Y is crucial for nutritional state-dependent regulation of maternal behavior.
Psychoneuroendocrinology. 51: 392-402, 2015

○ Yamashita, H., Muroi, Y., & Ishii, T.
Saccharin enhances neurite extension by regulating organization of the microtubules.
Life Sci. 93: 732-741, 2013

○ Yokoyama, S., Kinoshita, K., Muroi, Y., & Ishii, T.
The effects of bilateral lesions of the mesencephalic trigeminal sensory nucleus on nocturnal feeding and related behaviors in mice.
Life Sci. 93: 681-686, 2013

○ Nishie, H., Miyata, R., Fujikawa, R., Kinoshita, K., Muroi, Y., & Ishii, T.
Post-weaning mice fed exclusively milk have deficits in induction of long-term depression in the CA1 hippocampal region and spatial learning and memory.
Neurosci. Res. 73: 292-301, 2012

○ Muroi, Y. & Ishii, T.
Umami taste receptor functions as an amino acid sensor via Gαs subunit in N1E-115 neuroblastoma cells.
J. Cell. Biochem. 113: 1654-1662, 2012

○ Senda, A., Fukuda, K., Ishii, T., &. Urashima, T.
Changes in the bovine whey proteome during the early lactation period..
Anim. Sci. J. 82: 698-706, 2011

○ Ishii, T., Suenaga, R., Iwata, W., Miyata, R., Fujikawa, R., & Muroi, Y.
Bilateral lesions of the mesencephalic trigeminal sensory nucleus stimulate hippocampal neurogenesis but lead to severe deficits in spatial memory resetting.
Brain Res.1342: 74-84, 2010

○ Fujikawa, R., Muroi, Y., Unno, T., & Ishii, T.
Ouabain exacerbates botulinum neurotoxin-induced muscle paralysis via progression of muscle atrophy in mice.
J. Toxicol. Sci. 35: 795-805, 2010

○ Ishii, T., Uto, T., Mori, K., & Fujikawa, R.:
Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells.
Life Sci. 84: 530-536, 2009

○ Ishii, T.
Lactoferrin stimulates cell growth and survival in neuronal cells via activation of integrin-dependent signals.
Current Topics in Pharmacology (Review) 13: 67-73, 2009

○ Tanahashi, Y., Unno, T., Matsuyama, H., Ishii, T., Yamada, M., Wess, J., & Komori, S.:
Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells.
Br. J. Pharmacol. 158:1874-1883, 2009

○ Fukuda, K., Senda, A., Ishii, T., Urashima, T., Morita, M., & Terabayashi, T.:
Evidence for the presence of a putative odorant-binding protein in bovine colostrum.
J. Dairy Sci. 92:4992-4996, 2009

○ Fujikawa, R., Ishii, T., Komori, S., & Nishimura, M.:
Improved calcium utilization at motor nerve terminals exposed to botulium neurotoxin in mice.
J. Physiol. Sci. 58: 419-424, 2008

○ Yamamoto, M., Unno, T., Matsuyama, H., Kohda, M., Masuda, N., Nishimura, M., Ishii, T., & Komori, S.:
Two type of cation channel activated by stimulation of muscarinic receptors in guinea-pig urinary bladder smooth muscle.
J. Pharmacol. Sci. 108: 248-257, 2008

○ Ishii, T., Ishimori, H., Mori, K., Uto, T., Fukuda, K., Urashima, T., & Nishimura, M.:
Bovine lactoferrin stimulates anchorage-independent cell growth via membrane-associated chondroitin sulfate and heparan sulfate proteoglycans in PC12 cells.
J. Pharmacol. Sci. 104: 366-373, 2007

○ Ishii, T., Muranaka, R., Tashiro, O., & Nishimura, M.:
Chronic intracerebroventricular administration of anti-neuropeptide Y antibody stimulates starvation-induced feeding via compensatory responses in the hypothalamus.
Brain Res. 1144: 91-100, 2007

○ Muroi, Y., Ishii, T., Komori, S., Kitamura, N., & Nishimura, M.:
Sex steroids modulate the signals from volatile female odors in the accessory olfactory bulb of male mice.
Neurosci. Lett. 413: 11-15, 2007

○ Ishii, T., Furuoka, H., Kitamura, N., Muroi, Y., & Nishimura, M.:
The mesencephalic trigeminal sensory nucleus is involved in acquisition of active exploratory behavior induced by changing from a diet of exclusively milk formula to food pellets in mice.
Brain Res. 1111:153-161, 2006

○ Ishii, T., Nishimura, K., & Nishimura, M.:
Administration of xenobiotics with anti-estrogenic effects results in mRNA induction of adult male-specific cytochrome P450 (CYP) isozymes in the livers of adult female rats.
J.Pharmacol. Sci. 101: 250-255, 2006

○ Muroi, Y., Ishii, T., Komori, S., Kitamura, N., & Nishimura, M.:
Volatile female odors activate the accessory olfactory system of male mice without physical contact.
Neuroscience 141: 551-558, 2006

○ Muroi, Y., Ishii, T., Komori, S., & Nishimura, M.:
A competitive effect of androgen signaling on male mouse attraction to volatile female mouse odors.
Physiol. Behav. 87: 199-205, 2006

○ Ishii, T., Itou, T., & Nishimura, M.:
Comparison of growth and exploratory behavior in mice fed an exclusively milk formula diet and mice fed a food-pellet diet post weaning.
Life Sciences 78: 174-179, 2005

○ Saitoh, M., Ishii, T., Takewaki, T., & Nishimura, M.:
Preference for safflower oil in rats exposed to a cold environment under free-feeding conditions.
J. Vet. Med. Sci. 67: 653-658, 2005

○ Ishii, T., Furuoka, H., Itou, T., Kitamura, N., & Nishimura, M.:
The mesencephalic trigeminal sensory nucleus is involved in the control of feeding and exploratory behavior in mice.
Brain Res. 1048: 80-86, 2005

○ Ishii, T.
Role of integrin-linked kinase in neuronal cells.
Current Enzyme Inhibition. (Review) 1: 3-10, 2005

○ Muroi, Y., Ishii, T., Teramoto, K., Hori, M., & Nishimura, M.:
Calcineurin contributes to the enhancing effect of adenosine on nerve growth factor-induced neurite outgrowth via the decreased duration of p38 mitogen-activated protein kinase phosphorylation.
J.Pharmacol. Sci. 95: 124-131, 2004

○Ishii, T., Furuoka, H., Muroi, Y., & Nishimura, M. :
Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3βin N1E-115 neuroblastoma cells.
J. Biol. Chem. 278 (29): 26970-26975, 2003

○Satoh, E., Ishii, T., & Nishimura, M. :
Palytoxin-induced increase in cytosolic-free Ca2+ in mouse spleen cells.
Eur. J. Pharmacol. 465: 9-13, 2003

○Ito, K., Toyoda, I., Higashiyama, M., Uemura, D., Sato, M. H., Yoshimura, S.H., Ishii, T., & Takeyasu, K.:
Channel induction by palytoxin in yeast cells expressing Na+,K+-ATPase or its chimera with sarco/endoplasmic reticulum Ca2+-ATPase.
FEBS Lett. 543: 108-112, 2003

○Satoh, E., Ishii, T., Shimizu, Y., & Nishimura, M. :
A mechanism of the thearubigin fraction of black tea (Camellia sinensis) extract protecting against of the effect of tetanus toxin.
J. Toxicol. Sci. 27: 441-447, 2002

○Satoh, E., Ishii, T., Shimizu, Y., Sawamura, S., & Nishimura, M.:
The mechanism underlying the protective effect of the thearubigin fraction of black tea (Camellia sinensis) extract against the neuromuscular blocking action of botulinum neurotoxins.
Pharmacol. Toxicol. 90: 199-202, 2002

○Ishii, T., Satoh, E., & Nishimura, M. :
Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells.
J. Biol. Chem. 276 (46): 42994-43003, 2001

○Satoh, E., Ishii, T, Shimizu, Y., Sawamura, S., & Nishimura, M. :
Black tea extract, thearubigin fraction, counteracts the effects of tetanus toxin in mice.
Proc. Soc. Exp. Biol. Med. 226 (6): 577-580, 2001

○Satoh, E., Ishii, T, Shimizu, Y., Sawamura, S., & Nishimura, M. :
Black tea extract, thearubigin fraction, counteract the effects of botulinum neurotoxins in mice.
Brit. J. Pharmacol. 132: 797-798, 2001

○Satoh, E., Ishii, T, & Nishimura, M. :
The mechanism of maitotoxin-induced elevation of the cytosolic free calcium level in rat cerebrocortical synaptosomes.
Jpn. J. Pharmacol. 85:98-100, 2001.

○ Ishii, T., Yoshimura, S.H., and Takeyasu, K. :
Long-term Effect of Ouabain : Transcriptional Regulation of The Na/K-ATPase a1 Subunit Gene under Ouabain Treatment.
In "Na/K-ATPase and Related ATPases", 697-700, (Ed. K. Taniguchi & S. Kaya). ELSEVIER (Excerpta Medica, ICS 1207), 2000

○ Homareda H, Ishii T, & Takeyasu K :
Binding domain of oligomycin on Na(+),K(+)-ATPase.
Eur. J. Pharmacol 400 (2-3):177-183, 2000.

○ Homareda, H., Ishii, T., and Takeyasu, K. :
Effect of Oligomycin on Interaction of Na+ with Na+,K+-ATPase.
In "Na/K-ATPase and Related ATPases", 451-454, (Ed. K. Taniguchi & S. Kaya). ELSEVIER (Excerpta Medica, ICS 1207), 2000

○ Ishii, T., Sunami, O., Nakajima, H., Nishio, H., Takeuchi, T., & Hata, F. :
Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide.
Biochem. Pharmacol. 58(1):133-143, 1999.

○ Takeuchi, T., Kishi, M., Hirayama, N., Yamaji, M., Ishii, T., Nishio, H., Hata, F., & Takewaki, T. :
Tyrosine kinase involvement in apamin-sensitive inhibitory responses of rat distal colon.
J. Physiol. (Lond) 541(Pt 1): 177-188, 1999.

○ Ishii, T., Sunami, O., Saitoh, N., Nishio, H., Takeuchi, T., & Hata, F. :
Inhibition of skeletal muscle sarcoplasmic reticulum Ca2+-ATPase by nitric oxide.
FEBS Lett. 440: 218-222, 1998.

○ Takeuchi, T., Niioka, S., Yamaji, M., Okishio, Y., Ishii, T., Nishio, H., Takatuji, K., & Hata, F. :
Decrease in participation of nitric oxide in nonadrenergic, noncholinergic relaxation of rat intestine with age.
Jpn. J. Pharmacol. 78: 293-302, 1998.

○ Takeuchi, T., Niioka, S., Kishi, M., Ishii, T., Nishio, H., Hata, F., Takewaki, T., & Takatsuji, K. :
Nonadrenergic, noncholinergic relaxation mediated by nitric oxide with concomitant change in Ca2+ level in rectal circular muscle of rats.
Eur. J. Pharmacol. 353: 67-74, 1998.

○ Yoshimura, S.H., Vasilets, L.A., Ishii, T., Takeyasu, K., & Schwarz, W.:
The Na+, K+-ATPase carrying the carboxy-terminal Ca2+/ calmodulin binding domain of the Ca2+ pump has 2Na+, 2K+ stoichiometry and lost charge movement in Na+/Na+ exchange.
FEBS Lett. 425: 71-74, 1998.

○ Ishii, T., Hata, F., Lemas, M.V., Fambrough, D.M., & Takeyasu, K. :
Carboxy-terminal regions of the sarcoplasmic/endoplasmic reticulum Ca2+- and the Na+/K+-ATPases control their K+ sensitivity.
Biochemistry 36: 442-451, 1997.

○ Zhao, J., Vasilets, L.A., Gu, Q., Ishii, T., Takeyasu, K., & Schwarz, W. :
Transport\ activity of a chimeric Na+, K+-ATPase with Ca2+/calmodulin binding domain from Ca2+-ATPase in xenopus oocytes.
Ann. New York Acad. Sci., 834:372-375, 1997.

○ Yoshimura, S.H., Ishii, T., Yasuhara, J.C., Sato, M.H., & Takeyasu, K. :
Ion-sensitive domains of the SERCA- and the Na+/K+-ATPases Identified by Chimeric Recombination.
Ann. New York Acad. Sci., 834:588-591, 1997.

○ Zhao, J., Vasilets, L. A., Yoahimura, S., Gu, Q., Ishii, T., Takeyasu, K., & Schwarz, W.:
The Ca2+/ calmodulin binding domain of the Ca2+-ATPase linked to the Na+, K+-ATPase alters transport stoichiometry.
FEBS Lett. 408: 271-275, 1997.

○ Saito,N., Fujimoto,R., Ishii,T., Nishio,H., Takeuchi,T., & Hata,F.:
Muscarinic autoinhibition and modulatory role of protein kinase C in acetylcholine release from the myenteric plexus of guinea pig ileum.
Jpn. J. Pharmacol. 74: 155-163, 1997.

○ Niioka,S., Takeuchi,T., Kishi,M., Ishii,T., Nishio,H., Takewaki,T, & Hata,F.:
Nonadrenergic, noncholinergic relaxation in longitudinal muscle of rat jejunum.
Jpn. J. Pharmacol. 73: 155-161, 1997.

○ Kishi, M., Takeuchi,T., Suthamnatpong, N., Ishii, T., Nishio, H., Hata, F. & Takewaki, T.: VIP- and PACAP- mediate nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.
Brit. J. Pharmacol. 119: 623-630, 1996.

○ Takeuchi, T., Kishi, M., Ishii, T., Nishio, H., & Hata , F. :
Nitric oxide-mediated relaxation without concomitant change in cyclic GMP content of rat proximal colon.
Brit. J. Pharmacol., 117:, 1204-1208, 1996.

○ Fujita, A., Takeuchi, T., Ishii, T., Nishio, H., & Hata, F. :
Cooperation of ATP and norepinephrine in inducing contraction in guinea pig vas deferens is not associated with change in intracellular Ca2+ level.
Jpn. J. Pharmacol. 70: 273-276, 1996.

○ Ishii, T. & Takeyasu, K. :
The C-terminal 165 amino acids of the plasma membrane Ca2+-ATPase confer Ca2+/calmodulin sensitivity on the Na+, K+-ATPase a-Subunit.
EMBO J., 14: 58-67, 1995.

○ Takeuchi, T., Fujita, A., Ishii, T., Nishio H. & Hata, F.:
Necessity of newly synthesized ATP by creatine kinase for contraction of permeabilized longitudinal muscle preparations of rat proximal colon.
J. Pharmacol. Exp. Ther., 275: 429-434, 1995.

○ Ishii, T., Lemas, M.V. & Takeyasu, K. :
Na+-, ouabain-, Ca2+- and thapsigargin-sensitive ATPase activity expressed in chimeras between the calcium and the sodium pump a Subunits.
Proc. Natl. Acad. Sci. USA, 91: 6103-6107, 1994.

○ Yu, H.., Ishii, T., Peason, W. & Takeyasu, K. :
Primary structure of avian H/K-ATPase b-subunit.
Biochim.Biophys.Acta, 1190:189-192, 1994.

○ Takeyasu, K., Paul, J.K., Nettikadan, S.R., Wang, S., Ishii, T., Yu, H. & Yamaguchi, M.:
Imaging p-type ATPase molecules by force microscopy.
Microscopy and Analysis, 11: 25-27, 1994.

○ Ishii, T. & Takeyasu, K. :
Ca2+/calmodulin-sensitive Na+/K+-ATPase activity expressd in chimeric molecules between the plasma membrane Ca2+-ATPase and the Na+/K+-ATPase a-Subunit.
In "The Sodium Pump" , 86-89, (Ed. E. Bamberg & W.Schoner). D. Steinkopff Verlag, 1994.

○ Takeyasu, K., Paul, J.K., Ganjeizadeh, M., Lemas, M.V., Wang, S.-S., Yu, H.-Y., Kuwahara,T. & Ishii, T.:
Structure and function of ion pumps studied by atomic force microscopy and gene-transfer experiments using chimeric Na+/K+- and Ca2+-ATPase.
In "The Sodium Pump", 264-275, (Ed. E. Bamberg & W.Schoner). D.Steinkopff Verlag, 1994.

○ Ishii, T.& Takeyasu, K. :
The amino-terminal 200 amino acids of the plasma membrane Na, K-ATPase a-subunit confer ouabain-sensitivity on the sarcoplasmic reticulum Ca2+-ATPase.
Proc. Natl. Acad. Sci. USA
, 90: 8881-8885, 1993.

○ Sumbilla, C., Lu, L., Lewis, D., Inesi, G., Ishii, T., Takeyasu, K., Feng, Y. & Fambrough, D.M.:
Ca2+-dependent and tapsigargin-inhibited phosphorylation of Na,K-ATPase catalitic domain following chimeric recombination with Ca2+-ATPase.
J. Biol. Chem., 268: 21185-21192, 1993.

○ Kanada, A., Hata, F., Suthamnatpong, N., Maehara, T., Ishii, T., Takeuchi, T. & Yagasaki,O.:
Key roles of nitric oxide and cyclic GMP in nonadrenergic and noncholinergic inhibition in rat ileum.
Eur. J. Pharmacol. 216: 287-292, 1992.

○ Kishi, I., Hata, F., Takeuchi, T., Ishii, T. & Yagasaki, O. :
Cooperation of ATP and norepinephrine in inducing contractile responses in guinea pig vas deferens.
Jpn J. Pharmacol.
, 54: 253-256, 1990.

○ Hata, F., Ishii, T., Kanada, A., Yamano, N., Kataoka, T., Takeuchi, T. & Yagasaki, O. :
Essential role of nitric oxide in descending inhibition in the rat proximal colon.
Biochem. Biophs. Res. Commun. 172: 1400-1406, 1990.

○ Ishii, T., Miwa, T., Nishio, H. & Yagasaki, O. :
The biochemical and ultrastructural examinations in central cholinergic damage of the rat induced by the intraperitoneral administration of AF64A.
Jpn J. Pharmacol. 54: 415-423, 1990.