Publications

これまでに発表した論文(以前に所属していた研究室で発表したものも含みます)を紹介しています。

それぞれの論文のAbstractは末尾の[PubMed]などのリンクをクリックしていただければ、NCBI PubMedの抄録ページ等に移ります。

原著論文 Original Papers

  1. Toyotome T, hamada S, Yamaguchi S, Takahashi H, Kondoh D, Takino M, Kanesaki Y, Kamei K, "Comparative genome analysis of Aspergillus flavus clinically isolated in Japan", DNA Research, in press [PubMed]

  2. Horie M, Sato H, Tada A, Nakamura S, Sugino S, Tabei Y, Katoh M, Toyotome T, "Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha", Bioscience of Microbiota, Food and Health, in press [J-Stage]

  3. Tanaka Y, Toyotome T, Inokuma H, Watanabe K, Kobayashi Y, Horiuchi N, "Rhinocerebral Zygomycosis Due to a Lichtheimia ramosa Infection in a Calf: Neural Spread Through the Olfactory Nerves", Mycopathologia, in press [PubMed]

  4. Nakagun S, Okazaki M, Toyotome T, Sugiyama N, Watanabe K, Horiuchi N, Kobayashi Y, "Fatal Pulmonary and Cerebellar Zygomycosis due to Rhizomucor pusillus in a Ringed Seal (Pusa hispida)", Mycopathologia, in press [PubMed]

  5. Toyotome T, Hagiwara D, Watanabe A, Kamei K, "A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus", Med. Mycol., in press [PubMed]

  6. Takahashi-Nakaguchi A, Sakai K, Takahashi H, Hagiwara D, Toyotome T, Chibana H, Watanabe A, Yaguchi T, Yamaguchi M, Kamei K, Gonoi T, "Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses", Cell. Microbiol., 20, 2018 [PubMed]

  7. 中野美絵,山口英美,木元美樹,崔宝隠,松本高太郎,豊留孝仁,古岡秀文 "北海道十勝地方のエゾリス(Sciurus vulgaris orientis)およびドブネズミ(Rattus norvegicus)に見られたadiaspiromycosisの病理学的検索", Jpn. J. Zoo Wildl. Med., 22, 37-40, 2017 [J-Stage]

  8. Onishi K, Sarumoh BM, Hagiwara D, Watanabe A, Kamei K, Toyotome T, "Azole-resistant Aspergillus fumigatus containing a 34-bp tandem repeat in cyp51A promoter is isolated from the environment in Japan", Med. Mycol J., 58E, E67-E70, 2017 [PubMed]

  9. Toyotome T, Hagiwara D, Kida H, Ogi T, Watanabe A, Wada T, Komatsu R, Kamei K, "First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan.", J. Infect. Chemother., 23, 579-581, 2017 [PubMed]

  10. Toyotome T, Fujiwara T, Kida H, Matsumoto M, Wada T, Komatsu R, "Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan.", J. Infect. Chemother., 22, 648-650, 2016[PubMed]

  11. Toyotome T, Takahashi M, Kamei K, "MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect.", J. Toxicol. Sci., 41, 25-31, 2016[PubMed]

  12. Muraosa Y, Toyotome T, Yahiro M, Watanabe A, Shikanai-Yasuda MA, Kamei K, "Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR.", Med. Mycol., 54, 433-438, 2016[PubMed]

  13. Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H, "Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis.", Med. Mycol., 53, 353-360, 2015[PubMed]

  14. Toyotome T, Watanabe A, Ochiai E, Kamei K, "N-acetylated α-linked acidic dipeptidase is identified as an antigen of Histoplasma capsulatum.", Biochem. Biophys. Res. Commun., 458, 483-487, 2015[PubMed]

  15. Tamiya H, Ochiai E, Kikuchi K, Yahiro M, Toyotome T, Watanabe A, Yaguchi T, Kamei K, "Secondary metabolite profiles and antifungal drug susceptibility of Aspergillus fumigatus and closely related species, A. lentulus, A. udagawae, and A. viridinutans.", J. Infect. Chemother., 2015[PubMed]

  16. Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M,Sanada T, Suzuki T, Tsutsui H, Nunez G, Sasakawa C, "Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.", Proc. Natl. Acad. Sci. USA, 111, E4254-63, 2014[PubMed]

  17. Wuren T, Toyotome T, Yamaguchi M, Takahashi-Nakaguchi A, Muraosa Y, Yahiro M, Wang DN, Watanabe A, Taguchi H, Kamei K, "Effect of Serum Components on Biofilm For mation of Aspergillus fumigatus and non-fumigatus Aspergillus.", Jpn. J. Infect. Dis., 67, 172-179, 2014[PubMed]

  18. Wang DN, Toyotome T, Muraosa Y, Watanabe A, Wuren T, Bunsupa S, Aoyagi K, Yamazaki M, Takino M, Kamei K, "GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin.", Med. Mycol., 52, 506-518, 2014[PubMed]

  19. Toyotome T, Satoh M, Yahiro M, Watanabe A, Nomura F, Kamei K, "Glucoamylase is a major allergen of Schizophyllum commune.", Clin. Exp. Allergy, 44, 450-457, 2014[PubMed]

  20. Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, Kamei K, Gonoi T, Kawamoto S, "NikA/TcsC Histidine Kinase Is Involved in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigatus.", PLoS One, 8, e80881, 2013[PubMed]

  21. Toyotome T, Yamaguchi M, Iwasaki A, Watanabe A, Taguchi H, Qin L, Watanabe H, Kamei K, "Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus.", Int. J. Med. Microbiol., 302, 108-16, 2012[PubMed]

  22. Nagayoshi M, Tada Y, West J, Ochiai E, Watanabe A, Toyotome T, Tanabe N, Takiguchi Y, Shigeta A, Yasuda T, Shibuya K, Kamei K, Tatsumi K, "Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.", Mycopathologia, 172, 5-15, 2011[PubMed]

  23. Oarada M, Kamei K, Gonoi T, Tsuzuki T, Toyotome T, Hirasaka K, Nikawa T, Sato A, Kurita N, "Beneficial effects of a low-protein diet on host resistance to Paracoccidioides brasiliensis in mice.", Nutrition, 25, 954-963, 2009[PubMed]

  24. Toyotome T, Adachi Y, Watanabe A, Ochiai E, Ohno N, Kamei K, "Activator protein 1 is triggered by Aspergillus fumigatus beta-glucans surface-exposed during specific growth stages.", Microb. Pathog., 44, 141-150, 2008[PubMed]

  25. Ashida H, Toyotome T, Nagai T, Sasakawa C, "Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors.", Mol. Microbiol., 63, 680-693, 2007[PubMed]

  26. Oarada M, Gonoi T, Tsuzuki T, Igarashi M, Hirasaka K, Nikawa T, Onishi Y, Toyotome T, Kamei K, Miyazawa T, Nakagawa K, Kashima M, Kurita N, "Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice.", Biosci. Biotechnol. Biochem., 71, 174-182, 2007[PubMed]

  27. Suzuki T, Yoshikawa Y, Ashida H, Iwai H, Toyotome T, Matsui H, Sasakawa C, "High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin.", J. Immunol., 177, 4709-4717, 2006[PubMed]

  28. Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C, "Shigella effector IpaH9.8 binds to a splicing factor U2AF35 to modulate host immune responses.", Biochem. Biophys. Res. Commun., 333, 531-539, 2005[PubMed]

  29. Tamano K, Katayama E, Toyotome T, Sasakawa C, "Shigella Spa32 is an essential secretory protein for functional type III secretion machinery and uniformity of its needle length.", J. Bacteriol., 184, 1244-1252, 2002[PubMed]

  30. Toyotome T, Suzuki T, Kuwae A, Nonaka T, Fukuda H, Imajoh Ohmi S, Toyofuku T, Hori M, Sasakawa C, "Shigella protein IpaH9.8 is secreted from bacteria within mammalian cells and transported to the nucleus.", J. Biol. Chem., 276, 32071-32079, 2001[PubMed]

総説・プロシーディング Reviews and Proceedings

  1. Toyotome T, Hagiwara D, Takahashi H, Watanabe A, Kamei K, "Emerging Antifungal Drug Resistance in Aspergillus fumigatus and Among Other Species of Aspergillus", Current Fungal Infection Reports, in press [Springer]

  2. 高橋(中口)梓,萩原大祐,高橋弘喜,酒井香奈江,豊留孝仁,渡辺哲,亀井克彦,五ノ井透, "次世代シークエンサーを活用したオミクス解析によるAspergillus fumigatus病原因子探索", Medical Mycology Journal, 59J, J35-J40, 2018 [J-Stage] 日本語総説です

  3. 豊留孝仁, "原因真菌から見たアスペルギルス症", Medical Mycology Journal, 57J, 149J-154J, 2016 [J-Stage]日本語総説です

  4. 豊留孝仁, "アスペルギルス症におけるグリオトキシンの寄与", JSM Mycotoxins, 65, 109-113, 2015 [J-Stage]日本語プロシーディングです

  5. 亀井克彦, 渡辺哲, 豊留孝仁, "マルネッフェイ型ペニシリウム症", 別冊日本臨牀. 新領域症候群シリーズNo.24. 「感染症症候群(第2版 上 病原体別感染症編」, p.606-608, 2013

  6. 渡辺哲, 豊留孝仁, 亀井克彦, "アスペルギルス症-最近の知見 -成立メカニズム解明とその応用-", 小児内科, 44, 1012-1015, 2012

  7. 豊留孝仁, 亀井克彦, "病原真菌の病原機構と病原因子", 化学療法の領域, 28巻, 201-207, 2012

  8. Toyotome T, Watanabe A, Iwasaki A, Kamei K, "[Strategy of Aspergillus fumigatus to evade attacks from host--projectile weapons and armor]", Nippon. Ishinkin. Gakkai. Zasshi., 50, 139-145, 2009[PubMed]日本語総説です

  9. 豊留孝仁, 渡辺哲, 亀井克彦, "ゲノムプロテオーム解析による真菌病原因子の解明と抗真菌薬創薬への期待", 日本臨牀, 66巻, 2255-2260, 2008[PubMed]

  10. Watanabe A, Hashimoto Y, Higurashi H, Ochiai E, Toyotome T, Nagayoshi M, Kamei K, "[Candidates for virulence factors of Aspergillus fumigatus]", Nippon. Ishinkin. Gakkai. Zasshi., 49, 263-267, 2008[PubMed]日本語総説です

  11. 渡辺哲, 豊留孝仁, 亀井克彦, "ヒストプラズマ症", 別冊日本臨牀. 新領域別症候群シリーズNo.8. 「呼吸器症候群(第2版). I. -その他の呼吸器疾患を含めて-. I. 感染症呼吸器疾患. D. 真菌感染症」 p.184-187, 2008

著書 Books

  1. 豊留孝仁(分担), "第14章 真菌学 1. 真菌とは(p.458-465)", 「獣医微生物学 第4版」, 公益社団法人 日本獣医学会 微生物学分科会 編,関崎 勉/遠矢幸伸/福士秀人/堀本泰介/村瀬敏之 編集,文永道堂出版,2018年6月発行 文永堂出版サイト

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