メンバーの個別研究テーマと業績一覧です

メンバーの個別研究テーマと業績一覧です。

ABOGE

研究テーマ：

犬バベシア原虫感染症に対する新規診断・治療法の開発

研究業績

1. Goo, Y.K., Jia, H., Aboge, G.O., Terkawi, M.A., Kuriki, K., Nakamura, C., Kumagai, A., Zhou, J., Lee, E.G., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X.: Babesia gibsoni: Serodiagnosis of infection in dogs by an enzyme-linked immunosorbent assay with recombinant BgTRAP. Exp. Parasitol. (in press)

2. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Zhou, J., Lee, E.G., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X.: Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen. Exp. Parasitol. (in press)

3. Aboge, G.O., Jia, H., Terkawi, M.A., Goo, Y.K., Kuriki, K., Nishikawa, Y., Igarashi, I., Suzuki, H., Xuan, X.: A novel 57-kDa merozoite protein of Babesia gibsoni is a prospective antigen for diagnosis and serosurvey of canine babesiosis by enzyme-linked immunosorbent assay. Vet. Parasitol. 149: 85-94, 2007.

4. Aboge, G.O., Jia, H., Kuriki, K., Zhou, J., Nishikawa, Y., Igarashi, I., Fujisaki, K., Suzuki, H., Xuan, X.: Molecular characterization of a novel 32-kDa merozoite antigen of Babesia gibsoni with a better diagnostic performance by enzyme-linked immunosorbent assay. Parasitology 134: 1185-1194, 2007.

5. Terkawi, M.A., Jia, H., Aboge, G.O., Goo, Y.K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Fujisaki, K., Xuan, X.: A shared antigen among Babesia species: Ribosomal phosphoprotein P0 as a universal babesial vaccine candidate. Parasitol. Res. 102: 35-40, 2007.

ALAA

研究テーマ

バベシア原虫感染症に対するユニバーサルワクチン開発

研究業績：

4. Terkawi, M.A., Jia, H., Gabriel, A., Goo, Y.K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Fujisaki, K., Xuan, X.: A shared antigen among Babesia species: Ribosomal phosphoprotein P0 as a universal babesial vaccine candidate. Parasitol. Res. 102: 35-40, 2007.

5. Terkawi, M.A., Jia, H., Zhou, J., Lee, E.G., Igarashi, I., Fujisaki, K., Nishikawa, Y., Xuan, X.: Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B. microti infection in mice. Vaccine 25: 2027-2035, 2007.

張　国宏

研究テーマ

トキソプラズマ原虫感染症対するDNAワクチンの開発

研究業績：

1. Gong, H., Liao, M., Zhou, J., Hatta, T., Huang, P., Zhang, G., Kanuka, H., Nishikawa, Y., Xuan, X., Fujisaki, K.: Gene silencing of ribosomal protein P0 is lethal to the tick Haemaphysalis longicornis. Vet. Parasitol. (in press)

2. Zhang, G., Huong, T., Battur, J., Zhou, J., Zhang, H., Liao, M., Kawase, O., Lee, E.G., Dautu, G., Igarashi, M., Nishikawa, Y., Xuan, X.: A heterologous prime-boost vaccination regime using DNA and a vaccinia virus, both expressing GRA4, induced protective immunity against Toxoplasma gondii infection in mice. Parasitology 134: 1339-1346, 2007.

3. Kawase, O., Nishikawa, Y., Zhang, H., Zhang, G., Bannai, H., Jin, S., Lee, E.G., Xuan, X.: Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii. Prteomics 7: 3718-3725, 2007.

4. Dautu, G., Munyaka, B., Carmen, G., Zhang, G., Omata, Y., Xuan, X., Igarashi, M.: Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BGA1 and evaluation of their immunogenic potential. Exp. Parasitol. 116: 273-282, 2007.

5. Zhang, H., Lee, E.G., Liao, M., Comaore, M., Zhang, G., Kawase, O., Fujisaki, K., Sugimoto, C., Nishikawa, Y., Xuan, X.: Identification of ribosomal phosphoprotein P0 of Neospora caninim as a potential common vaccine candidate for the control of both neosporosis and toxoplasmosis. Mol. Biochem. Parasitol. 153: 141-148, 2007.

6. Zhang, H., Compaore, M., Lee, E.G., Liao, M., Zhang, G., Sugimoto, C., Nishikawa, Y, Xuan, X.: Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and anti-NcAMA1 antibody inhibit host cell invasion by both parasites. Mol. Biochem. Paarasitol. 151: 205-212, 2007.

7. Zhou, J., Zhang, G., Verdida, R. A., Nishikawa, Y., Fujisaki, K., Xuan, X.: A 38-kDa protein from Babesia gibsoni and its antibody response in an experimentally infected dog. Vet. Parasitol. 141: 345-348, 2006.

8. Zhou, J., Yang, J., Zhang, G., Nishikawa, Y., Fujisaki, K., Xuan, X.: Babesia gibsoni: an apical membrane antigen-1 homologue and its antibody response in the infected dogs. Exp. Parasitol. 114: 329-333, 2006.

9. Zhou, J., Zhang, G., Fukumoto, S., Yokoyama, N., Suzuki, H., Igarashi, I., Fujisaki, K., Lin, J., Xuan, X.: A Babesia gibsoni thrombospondin related anonymous protein (BgTRAP) is an immunodominant antigen involved in the erythrocyte invasion. Mol. Biochem. Parasitol. 148: 190-198, 2006.

10. Chahan, B., Zhang, S., Seo, J., Nakamura, C., Zhang, G., Bannai, H., Jian, Z., Inokuma, H., Tuchiya, K., Sato, Y., Kabeya, H., Maruyama, S., Mikami, T., Xuan, X.: Seroepidemiological evidence for the possible presence of Babesia (Theileria) equi and Babesia caballi infections in donkeys in Western Xinjiang, China. J. Vet. Med. Sci. 68: 753-755, 2006.

11. Hara, O., Min, L., Baticados, W., Bannai, H., Zhang, G., Zhang, S., Lee, E.G., Nishikawa, Y., Claveria, F., Igarashi, M., Nagasawa, H., Xuan, X.: Expression of recombinant dense granule protein 7 of Neospora caninum and evaluation of its diagnostic potential for canine neosporosis. J. Protozool. Res. 16: 34-41, 2006.

12. Liao, M., Xuan, X., Zhang, S., Zhang, G., Huang, X., Igarashi, I., Fujisakia, K.: Development of a rapid immunochromatographic test with recombinant NcSAG1 for detection of Neospora caninum infection in cattle. Clin. Diagn. Lab. Immunol. 12: 885-887, 2005.

張　厚双

研究テーマ：

トキソプラズマ原虫とネオスポラ原虫の共通抗原の探索と両原虫感染症に対する共通ワクチンの開発

研究業績

1. Nishikawa, Y., Zhang, H., Ibrahim, H. M., Ui, F., Ogiso, A., Xuan, X.: Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein. Parasitol. Int. (in press)

2. Huang, P., Liao, M., Zhang, H., Lee, E.G., Nishikawa, Y., Xuan, X.: The dense granule protein NcGRA7, a new marker for the serodiagnosis of Neospora infection in aborting cows. Clin. Vaccine Immunol. 14: 1640-1643, 2007.

3. Zhang, G., Huong, T., Battur, J., Zhou, J., Zhang, H., Liao, M., Kawase, O., Lee, E.G., Dautu, G., Igarashi, M., Nishikawa, Y., Xuan, X.: A heterologous prime-boost vaccination regime using DNA and a vaccinia virus, both expressing GRA4, induced protective immunity against Toxoplasma gondii infection in mice. Parasitology 134: 1339-1346, 2007.

4. Kawase, O., Nishikawa, Y., Zhang, H., Zhang, G., Bannai, H., Jin, S., Lee, E.G., Xuan, X.: Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii. Prteomics 7: 3718-3725, 2007.

7. Laio, M., Ma, L., Bannai, H., Lee, E.G., Zhang, H., Xuan, X., Fujisaki, K.: Identification of a protein disulfide isomerase of Neospora caninum in excretory-secretory products and its IgA binding and enzymatic activities. Vet. Parasitol. 139: 47-56, 2006.

賈　洪林

研究テーマ：

犬バベシア原虫感染症に対する新規診断・治療法の開発

研究業績

5. Terkawi, M.A., Jia, H., Gabriel, A., Goo, Y.K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Fujisaki, K., Xuan, X.: A shared antigen among Babesia species: Ribosomal phosphoprotein P0 as a universal babesial vaccine candidate. Parasitol. Res. 102: 35-40, 2007.

6. Jia, H., Liao, M., Lee, E.G., Nishikawa, Y., Inokuma, H., Ikadai, H., Matsuu, A., Igarashi, I., Xuan, X.: Development of an immunochromatographic test with recombinant BgSA1 for the diagnosis of Babesia gibsoni infection in dogs. Parasitol. Res. 100: 1381-1384, 2007.

7. Zhou, J., Jia, H., Nishikawa, Y., Fujisaki, K., Xuan, X.: Babesia gibsoni rhoptry-associated protein 1 and its potential use as a diagnostic antigen. Vet. Parasitol. 145: 16-20, 2007.

8. Terkawi, M.A., Jia, H., Zhou, J., Lee, E.G., Igarashi, I., Fujisaki, K., Nishikawa, Y., Xuan, X.: Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B. microti infection in mice. Vaccine 25: 2027-2035, 2007.

9. Jia, H., Zhou, J., Ikadai, H., Matsuu, A., Suzuki, H., Igarashi, I., Fujisaki, K., Xuan, X.: Identification of a novel gene encoding a secreted antigen 1 of Babesia gibsoni and evaluation of its potential use in serodiagnosis. Am. J. Trop. Med. Hyg. 75: 843-850, 2006.

GONG

研究テーマ：

マダニの生物活性分子の分子生物学的研究

研究業績

1. Gong, H., Zhou, J., Liao, M., Hatta, T., Harnnoi, T., Umemiya, R., Inoue, N., Xuan, X., Fujisaki, K.: Characterization of a carboxypeptidase inhibitor from the tick Haemaphysalis longicornis. J. Insect. Physiol. 53: 1079-1087, 2007.

2. Gong, H., Liao, M., Zhou, J., Hatta, T., Huang, P., Zhang, G., Kanuka, H., Nishikawa, Y., Xuan, X., Fujisaki, K.: Gene silencing of ribosomal protein P0 is lethal to the tick Haemaphysalis longicornis. Vet. Parasitol. (in press)

3. Liao, M., Hatta, T., Umemiya, R., Huang, P., Jia, H., Gong, H., Zhou, J., Nishikawa, Y., Xuan, X., Fujisaki, K.: Identification of three protein disulfide isomerase members from Haemaphysalis longicornis tick. Insect Biochem. Mol. Biol. 37: 641-654, 2007.

4. Hatta, T., Umemiya, R., Liao, M., Gong, H., Harnnoi, T., Tanaka, M., Miyoshi, T., Boldbaatar, D., Battsetseg, B., Zhou, J., Xuan, X., Tsuji, N., Taylor, D., Fujisaki, K.: RNA interference of cytosolic leucine aminopeptidase reduces fecundity in the hard tick, Haemaphysalis longicornis. Parasitol. Res. 100: 847-854, 2007.

5. Zhou, J., Gong, H., Zhou, Y., Xuan, X., Fujisaki, K.: Identification of a glycine-rich protein from the tick Rhipicephalus haemaphysaloides and evaluation of its vaccine potential against tick feeding. Parasitol. Res. 100: 77-84, 2006.

具　潤景

研究テーマ：

犬バベシア原虫感染症に対する新規診断・予防法の開発

研究業績

4. Terkawi, M.A., Jia, H., Aboge, G.O., Goo, Y.K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Fujisaki, K., Xuan, X.: A shared antigen among Babesia species: Ribosomal phosphoprotein P0 as a universal babesial vaccine candidate. Parasitol. Res. 102: 35-40, 2007.

Hany Ibrahim

研究テーマ：

原虫由来宿主免疫撹乱物質の同定と機能解析

研究業績

1. Nishikawa Y, Zhang H, Ibrahim MH, Ui F, Ogiso A, Xuan X. Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein. Parasitol. Int. 2007 (In press)

ブーヤン

研究テーマ：

アジア各国における動物トキソプラズマ原虫感染症に対する疫学調査

宇井　史希

研究テーマ：

I型インターフェロンの抗原虫作用に関する解析

研究業績

1. Nishikawa Y, Zhang H, Ibrahim MH, Ui F, Ogiso A, Xuan X. Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein. Parasitol. Int. 2007 (In press)

小木曽　綾子

研究テーマ：

原虫感染における宿主シアル酸の役割について

研究業績

1. Nishikawa Y, Zhang H, Ibrahim MH, Ui F, Ogiso A, Xuan X. Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein. Parasitol. Int. 2007 (In press)

重城

研究テーマ

抗原虫天然物質の探索

山田　京子

研究テーマ：

抗がん作用をもつ原虫由来生理活性物質の同定とその作用機序の解明

TAWIN

研究テーマ

タイにおける動物原虫感染症の疫学調査